| Thursday September 2, 2010 | Previews |
| 7:05 PM | Boston at Baltimore
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| 7:10 PM | NY Mets at Atlanta
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| 8:10 PM | Detroit at Minnesota
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| 10:10 PM | Cleveland at Seattle
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| Friday September 3, 2010 | Previews |
| 1:05 PM | Toronto at NY Yankees
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| 2:20 PM | NY Mets at Chi Cubs
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| 7:05 PM | Milwaukee at Philadelphia
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| 7:05 PM | Washington at Pittsburgh
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| 7:05 PM | Tampa Bay at Baltimore
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| 7:10 PM | Chi White Sox at Boston
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| 7:10 PM | Atlanta at Florida
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| 8:10 PM | Detroit at Kansas City
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| 8:10 PM | Texas at Minnesota
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| 8:15 PM | Cincinnati at St. Louis
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| 9:40 PM | Houston at Arizona
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| 10:05 PM | Colorado at San Diego
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| 10:05 PM | LA Angels at Oakland
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| 10:10 PM | Cleveland at Seattle
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| 10:10 PM | San Francisco at LA Dodgers
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